Ozone Therapy can be given as supportive treatment to modern anti-tuberculosis treatment, in order to overcome resistance as well as to improve the immunity of the affected individual. Ozone Therapy for tuberculosis is therefore aimed at treating the main tuberculosis infection as well as substantially improving the immune status of the affected individual in order to help the diseased body fight against the infection and overcome it. Ozone Therapy which has a specific antibacterial action, especially for tuberculosis, is used in high doses for periods ranging from four months to twelve months, in order to overcome the tuberculosis infection. The side effects and toxicity of any ongoing conventional anti-tuberculosis medications can be considerably reduced by adding Ozone Therapy which has a specific action on the liver and kidneys. Immunomodulatory Ozone Therapy improves the immunity of the affected individual, reduces treatment time, and helps to maintain the strength and vitality of the patient. In addition, Ozone Therapy is also used to boost the immunity of the affected individual specifically for the tuberculosis infection and more so for the entire respiratory tract, which is affected most with tuberculosis infection. Aggressive and regular treatment with Ozone Therapy can also serve to treat multiple drug-resistant tuberculosis, bring about a complete remission from the disease, and improve the lifespan and quality of life of the affected individual. Ozone Therapy can thus be judiciously utilized in the management and treatment of tuberculosis.